Longitudinal probabilities for handicaps in the neurodegenerative dementias

 
   Lead Investigator:    Chiadi Onyike
   Institution      :    Johns Hopkins University
   E-Mail           :    conyike1@johnshopkins.edu
   Proposal ID      :    1293



   Proposal Description:
   The goal of this project is to describe and compare the probabilities of specific handicaps (i.e., functional losses) in patients with neurodegenerative dementias (AD, FTD, DLB and others).  Specific aim 1: describe probabilities for transition to specific handicaps  (i.e., specific IADL and ADL losses) conditioned on demographic status, CDR category, duration of illness and tempo of progression.                           Specific aim 2: identify the relative effects of comorbid states (e.g., parkinsonism) on the conditioned probability of specific handicaps                Specific aim 3: examine difference between dementia types in the probability of specific handicaps as a function of cognitive status and illness duration.        Specific aim 4: translate the probabilities into actuarial tables for clinical  reference.